GIUSEPPE ZANOTTI

Publications

Over the course of my scientific career, I have published more than 230 articles in international journals. Some of them marked important moments in my path: the discovery of new structures, the transition from one technique to another, and the opening of unexpected questions.

Below is a selected list. These are papers dealing with viruses, toxins, human and bacterial proteins, as well as with ideas such as tensegrity applied to proteins. They are stories of molecules, but also of collaborations, experiments, and insights. Selected publications:

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  • GRINZATO A, KANDIAH E, LICO C, BETTI C, BASCIERI S, ZANOTTI G. Atomic structure of potato virus X, the protorype of the Alphaflexiviridae virus family (2020) Nature Chem. Biol. 564-569. doi.org/10.1038/s41589-020-0502-4
  • BERCSENYI, N. SCHMIEG, J. B. BRYSON, M. WALLACE, P. CACCIN, M. GOLDING, G. ZANOTTI, L. GREENSMITH, R. NISCHT, G. SCHIAVO “Nidogens are therapeutic targets for the prevention of tetanus” Science, (2014) 346, 1118-1123 doi: 10.1126/science.1258138
  • MONTECUCCO C. AND ZANOTTI G., Botulinum neurotoxin A1 likes it double sweet, Nature Struct. Mol. Biol.(2016) 23, 619-621.
  • RAMAZZINA, R. COSTA, L. CENDRON, R. BERNI, A. PERACCHI, G. ZANOTTI, AND R. PERCUDANI “An aminotransferase branch point connects purine catabolism to amino acid recycling” Nature Chem. (2010), 6, 801-806, doi:10.1038/NCHEMBIO.445
  • FOLLI, V. CALDERONE, S. OTTONELLO, A. BOLCHI, G. ZANOTTI, M. STOPPINI AND R. BERNI ” Identification, retinoid binding and X-ray analysis of a novel human retinol-binding protein” Proc. Nat. Acad. Sci.(2001) 98, 3710-3715
  • ZANOTTI G. Intrinsic disorder and flexibility in proteins: a challenge for structural biology and drug design (2023) Crystallography Reviews, doi.org/10.1080/0889311X.2023.2208518
  • ZANOTTI G, GRINZATO A. Structure of filamentous viruses (2021) Current Opinion in Virology, 51 doi: 10.1016/j.coviro.2021.09.006
  • PIRAZZINI M, GRINZATO A, CORTI D, BARBIERI S, LEKA O, VALLESE F, TONELLATO M, SILACCI-FREGNI C, PICCOLI L, KANDIAH E, SCHIAVO G, ZANOTTI G, LANZAVECCHIA A, MONTECUCCO C. Exceptionally potent human monoclonal antibodies are effective for prophylaxis and treatment of tetanus in mice. J Clin Invest. 2021 131(22):e151676. doi: 10.1172/JCI151676
  • ZANOTTI G, VALLESE F, FERRARI A, MENOZZI I, SALDANO T.E., FERNANDEZ-ALBERTI S. AND BERNI R. Structural and dynamics evidence for scaffold asymmetric flexibility of the human transthyretin tetramer (2017), Plos ONE12(12),e0187716
  • LUNELLI, M.L. DI PAOLO, M. BIADENE, V. CALDERONE, R. BATTISTUTTA, M. SCARPA, A. RIGO AND G. ZANOTTI “Crystal structure of amine oxidase from bovine serum” J. Mol. Biol.(2005) 346, 991-1004
  • CENDRON, P. BERTO, S. D’ADAMO, F. VALLESE, C. GOVONI, M.C. POSEWITZ, G.M GIACOMETTI, P. COSTANTINI, G. ZANOTTI “Crystal structure of HydF scaffold protein provides insights into [FeFe]-hydrogenase maturation” J. Biol. Chem.(2011), 286, 43944-43950 DOI: 10.1074/jbc.M111.281956.
  • ZANOTTI AND C. GUERRA “Is tensegrity an unifying concept of protein folds?” FEBS letters(2003), 534, 7-10
  • ZANOTTI, R. BERNI and H.L. MONACO “Crystal Structure of Liganded and Unliganded Forms of Bovine Plasma Retinol-Binding Protein” J. Biol. Chem. (1993) 268, 10728-10738